Magnesium → HCID 69428791, compound

Participants

Reaction Steps

3.78 g (9 mmol, 1eq) (E)- and/or (Z)-(2S,4R)-2-(2-Ethoxycarbonyl-vinyl)-4-(4-methoxy-benzylsulfanyl)-pyrrolidine-1-carboxylic acid tert-butyl ester in 42 ml MeOH were treated with 1.32 g (54 mmol, 6 eq) magnesium at RT for 5 h. The solvent was evaporated, the crude product dissolved in EtOAc and filtered from the solid particles. This process was repeated, the solvent evaporated yielding 3.67 g (quant) (2R,4R)-4-(4-Methoxy-benzylsulfanyl)-2-(2-methoxycarbonyl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester as colorless oil, MS: 410 (MH+).

Provenance & Evidence