Hydrochloric Acid → HCID 70000245, compound

Participants

Reaction Steps

185 mg (0.37 mmol, 1eq) (2R,4R)-3-[4-(4-Methoxy-benzylsulfanyl)-1-(naphthalene-2-sulfonyl)-pyrrolidin-2-yl]-propionic acid methyl ester in 5 ml EtOH were treated with 1.85 ml 1M NaOH (1.85 mmol, 5 eq) for 2 h at RT, the pH was adjusted to 7 by the addition of 1M HCl, the solvent was evaporated and the crude product redissolved in EtOH and filtered from solids and evaporated, yielding 170 mg (94%) (2R,4R)-3-[4-(4-Methoxy-benzylsulfanyl)-1-(naphthalene-2-sulfonyl)-pyrrolidin-2-yl]-propionic acid as brown gum, MS: 486 (MH+).

Provenance & Evidence