Lithium Hydroxide → HCID 86585068, compound

Participants

Reaction Steps

To 106 mg (0.17 mmol) (2S,4R)-4-[[[[4-Acetylsulfanyl-1-(biphenyl-4-sulfonyl)-pyrrolidine-2-carbonyl]-methyl-amino]-acetyl]-methyl-amino]-benzoic acid methyl ester in 10 ml THF were added 10 ml 0.1 M LiOH at 0° C. and the solution was stirred at RT for 2 h, poured on 2 ml 1M KHSO4 and extracted with EtOAc. The combined organic layers were washed with brine and were dried with Na2SO4. The residue was titrurated with hexane to give 67 mg (69%) (2S,4R)-4-[[[[1-(Biphenyl-4-sulfonyl)-4-mercapto-pyrrolidine-2-carbonyl]-methyl-amino]-acetyl]-methyl-amino]-benzoic acid as white solid, MS: 568 (MH+).

Provenance & Evidence