Trifluoroacetic acid → HCID 70002907, compound

Participants

Reaction Steps

19176 B73: A solution of 9.68 g (16.33 mmol) (2S,4R)-2-(Benzyl-methyl-carbamoyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester in 33 ml CH2Cl2 was treated at −20° C. with 36 ml TFA, warmed up to RT during 5.5h and kept over night at 0° C.. The reaction was evaporated and treated with aqueous saturated NaHCO3 solution/EtOAc (3×), the organic phase was dried (Na2SO4) and evaporated to give 7.59 g (95%) (2S,4R)-4-Tritylsulfanyl-pyrrolidine-2-carboxylic acid benzyl-methyl-amide, MS: 493 (MH+).

Provenance & Evidence