1-Methylimidazole → HCID 21087646, compound

Participants

Reaction Steps

4.45 ml of N-methylimidazole (56 mmol) were added to a suspension of 5 g of 2-chloro-N-(3,5-dichloro-2-hydroxy-4-methylphenyl)acetamide (18.6 mmol), obtained above in the preceding step, in 5 ml of ethyl acetate, leading to a clear solution. After 3 hours and 30 minutes, the insoluble product which formed was drained and abundantly washed with ethyl acetate. The new precipitate which formed in the filtrates was drained and abundantly washed with ethyl acetate. The white powders thus obtained were combined and dried to give 5 g of 3-[(3,5-dichloro-2-hydroxy-4-methylphenylcarbamoyl)methyl]-1-methyl-3H-imidazol-1-ium chloride whose melting point was 251° C., (yield 77%).

Provenance & Evidence