HRID1264554

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID80407

4-Methoxybenzenemethanethiol

C8H10OS

结构：CNC(=O)C(Cc1ccccc1)N1Cc2ccccc2CC(NC(=O)C(Br)CCCCN2C(=O)c3ccccc3C2=O)C1=O

HCID131723841

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)C(Cc1ccccc1)N1Cc2ccccc2CC(NC(=O)C(CCCCN2C(=O)c3ccccc3C2=O)SCc2ccc(OC)cc2)C1=O

HCID131723843

未命名化合物

PROCEDURE

实验过程

Prepare by the method of Example 3.2 using 2-(4-(2-bromo-6-phthalimidohexanoyl-amino)-3-oxo-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl)-3-phenyl-propionic acid, N-methyl amide and p-methoxybenzylmercaptan to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-db56811d089440d5a7cfb4e54a9ecc99
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06544980B2
来源说明: uspto-grants-2003_04

反应 SMILES

[CH3:1][NH:2][C:3](=[O:44])[CH:4]([N:12]1[C:18](=[O:19])[CH:17]([NH:20][C:21](=[O:39])[CH:22](Br)[CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]3=[CH:33][CH:34]=[CH:35][CH:36]=[C:29]3[C:28]2=[O:37])[CH2:16][C:15]2[CH:40]=[CH:41][CH:42]=[CH:43][C:14]=2[CH2:13]1)[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH3:45][O:46][C:47]1[CH:54]=[CH:53][C:50]([CH2:51][SH:52])=[CH:49][CH:48]=1>>[CH3:1][NH:2][C:3](=[O:44])[CH:4]([N:12]1[C:18](=[O:19])[CH:17]([NH:20][C:21](=[O:39])[CH:22]([S:52][CH2:51][C:50]2[CH:53]=[CH:54][C:47]([O:46][CH3:45])=[CH:48][CH:49]=2)[CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]3=[CH:33][CH:34]=[CH:35][CH:36]=[C:29]3[C:28]2=[O:37])[CH2:16][C:15]2[CH:40]=[CH:41][CH:42]=[CH:43][C:14]=2[CH2:13]1)[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1