4-Methoxy-alpha-toluenethiol → HCID 131723843, compound

HRID 1264554Notes

Reaction equation

HRID 1264554 reaction equation
[CH3:1][NH:2][C:3](=[O:44])[CH:4]([N:12]1[C:18](=[O:19])[CH:17]([NH:20][C:21](=[O:39])[CH:22](Br)[CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]3=[CH:33][CH:34]=[CH:35][CH:36]=[C:29]3[C:28]2=[O:37])[CH2:16][C:15]2[CH:40]=[CH:41][CH:42]=[CH:43][C:14]=2[CH2:13]1)[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH3:45][O:46][C:47]1[CH:54]=[CH:53][C:50]([CH2:51][SH:52])=[CH:49][CH:48]=1>>[CH3:1][NH:2][C:3](=[O:44])[CH:4]([N:12]1[C:18](=[O:19])[CH:17]([NH:20][C:21](=[O:39])[CH:22]([S:52][CH2:51][C:50]2[CH:53]=[CH:54][C:47]([O:46][CH3:45])=[CH:48][CH:49]=2)[CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]3=[CH:33][CH:34]=[CH:35][CH:36]=[C:29]3[C:28]2=[O:37])[CH2:16][C:15]2[CH:40]=[CH:41][CH:42]=[CH:43][C:14]=2[CH2:13]1)[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 804074-Methoxy-alpha-toluenethiolHCID 1317238412-(4-(2-bromo-6-phthalimidohexanoyl-amino)-3-oxo-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl)-3-phenyl-propionic acid, N-methyl amide

Product 1

HCID 131723843HCID 131723843, compound

Procedure

Prepare by the method of Example 3.2 using 2-(4-(2-bromo-6-phthalimidohexanoyl-amino)-3-oxo-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl)-3-phenyl-propionic acid, N-methyl amide and p-methoxybenzylmercaptan to give the title compound.

Sources & evidence

ORD record
ord-db56811d089440d5a7cfb4e54a9ecc99
Source dataset
uspto-grants-2003_04
Patent number
US06544980B2

Reaction notes

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