Pyridine → HCID 18612947, compound

Participants

Reaction Conditions

Reaction Steps

To 0.50 g (1.26 mmol) of 2-[(2-aminobenzyl)-(4-methoxybenzenesulfonyl)amino]-3-hydroxypropionate in 5 ml of pyridine cooled to 0° C. was added 0.284 g (2.59 mmol) of tosyl chloride. The mixture was stirred at 0° C. for 2 hours and then concentrated to remove the solvent. To the residue was added 8 ml of anhydrous ethanol and the mixture refluxed for 2 days. The mixture was concentrated to dryness and ethyl acetate added. The mixture was washed with H2O, 2 N citric acid, brine and dried with Na2SO4. The filtrate was filtered through a thin pad of hydrous magnesium silicate and the filter pad washed with ethyl acetate. The filtrate was concentrated to dryness to give 0.60 g of a foam. Anal. for C25H26N2O7S2: Calc'd: C, 56.6; H, 4.9; N, 5.3; S, 12.1; Found: C, 56.2; H, 5.2; N, 5.2; S, 11.4.

Provenance & Evidence