Sodium Hydroxide → HCID 18612994, compound

Participants

Reaction Steps

A mixture of 1.0 g (2.3 mmol) of methyl 4-(4-methoxybenzenesulfonyl)-1-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate and 3.0 ml of 1 N NaOH in 10 ml of tetrahydrofuran was stirred at room temperature for 2 hours and the solvent removed. To the residue was added water and the mixture acidified with 1 N HCl. The mixture was extracted with ethyl acetate and the extract was washed with brine and dried with Na2SO4. The solvent was removed and the residue triturated with ethyl acetate-hexane, cooled and filtered to give 0.65 g of white crystals, m.p. 164°-165° C.; Mass spectrum (ES) 421.4 (M+H). Anal. for C20H24N2O6S: Calc'd: C, 57.1; H, 5.8; N, 6.7; Found: C, 57.3; H, 5.7; N, 6.4.

Provenance & Evidence