m-Toluidine → HCID 86584498, compound

Participants

Reaction Conditions

Reaction Steps

3-Methylaniline (32.2 mg, 0.250 mmol) and [bis (methylthio)methylene]propanedinitrile (35.5 mg, 0.209 mmol) were dissolved in ethanol(0.3 mL). The reaction mixture was heated at 80° C. for 3 h. To the mixture was added 1-[[(3S) -3-aminohexahydro-2-oxo-1H-azepin-1-yl]acetyl]pyrrolidine (50.0 mg, 0.209 mmol) and the reaction mixture was heated at 80° C. for another 40 h. Purification by preparative RP HPLC provided the title compound as a pale yellow solid (22 mg, 45%): MS (ESI, pos. ion spectrum) m/z 421; HPLC (method A) tR 3.39 min.

Provenance & Evidence