反应详情

A mixture of methanol (60 ml) and sulfuric acid (5.2 ml) was stirred at room temperature. 5-Chloro-2,3-dihydroxybenzoic acid (0.11 mol) was added. The reaction mixture was stirred and refluxed for 20 hours, and then poured out onto ice. The precipitate was filtered off, washed with water, and dried, yielding 18.48 g of methyl 5-chloro-2,3-dihydroxybenzoate (intermediate 9; mp: 102° C.).

1. stirringThe reaction mixture was stirred
2. temperaturerefluxed for 20 hours
3. additionpoured out onto ice
4. filtrationThe precipitate was filtered off
5. washwashed with water
6. customdried