HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl pyruvate → N-(2-methylquinolin-6-yl)alanine Iso-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl pyruvate | HCID 83084 | — |
| Reactant | 2-Methylquinolin-6-amine | HCID 103148 | — |
| Product | N-(2-methylquinolin-6-yl)alanine Iso-butyl Ester | HCID 54119157 | — |
Reaction Steps
Following General Procedure AA above and using 6-amino-2-methylquinoline (Lancaster) and iso-butyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared. The reaction was monitored by silica gel tlc (Rf=0.44 in 50% EtOAc/hexanes). Purification was by flash chromatography (silica gel using 50% EtOAc/hexanes as the eluant).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544978B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-33b8c4e178814be1bfd5607779133424 |
| Source note | uspto-grants-2003_04 |