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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1264804Generated: October 30, 2026

Methyl pyruvate → N-(3,4-ethylenedioxyphenyl)alanine Iso-butyl Ester

https://huagongshe.com/reaction/1264804

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl pyruvateHCID 11748—
ReactantN-(3,4-ethylenedioxyphenyl)alanine methyl esterHCID 53867794—
SolventIsobutanolHCID 6560—
ProductN-(3,4-ethylenedioxyphenyl)alanine Iso-butyl EsterHCID 53856555—

Reaction Steps

Following reductive amination General Procedure AA above and using 1,4-benzodioxa-6-amine (Aldrich) and methyl pyruvate (Aldrich), N-(3,4-ethylenedioxyphenyl)alanine methyl ester was prepared. The methyl ester was then transesterified following General Procedure AQ above using iso-butanol to provide the title compound. Purification was by preparative plate chromatography.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06544978B2
Source datasetuspto-grants-2003_04
ORD IDord-07fb82f9f658429a98d46751c29df002
Source noteuspto-grants-2003_04