(4-Chlorophenyl)acetic acid → 2-[(4chlorophenyI)acetamido]butyric acid iso-butyl ester

HRID 1264829Notes

Reaction equation

HRID 1264829 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 540487372-[(4chlorophenyI)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 4-chlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-baf83d3ef3b14cb3923b59d0e3392452
Source dataset
uspto-grants-2003_04
Patent number
US06544978B2

Reaction notes

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