2-(3,5-Dichlorophenyl)acetic acid → 2-[(3,5-dichlorophenyl)acetamido]hexanoic Acid Methyl Ester

Participants

Reaction Steps

Following General Procedure BF above, an using 3,5-dichlorophenylacetic acid (from Example BC above) and L-norleucine methyl ester hydrochloride (Bachem), the title compound was prepared as a solid having a melting point of 77-78° C. The reaction was monitored by tlc on silica gel (Rf=0.70 in 40% EtOAC/hexanes) and purification was by flash chromatography on silica gel using 40% EtOAc/hexanes as the eluant.

Provenance & Evidence