1,8-Diazabicyclo(5.4.0)undec-7-ene → 7-Chloro-2-(2-furyl)-5-methylthio[1,2,4]triazolo[1,5-c]pyrimidine

Participants

Reaction Steps

Into 8.5 mL of THF, 2.7 g (10 mmol) of Compound B was dissolved, and 1.5 mL (10 mmol) of DBU was added thereto under ice cooling, followed by stirring at room temperature for about 1 hour. During the period, crystals were precipitated from the reaction solution. After completion of the reaction, the precipitated solid was washed with THF to obtain 2.1 g of Compound C as a white solid (yield: 81%).

Provenance & Evidence