Methylamine → HCID 18613744, compound

Participants

Reaction Steps

The bromide (25) (190 mg, 0.64 mmol) was dissolved in a 33% solution of methylamine in ethanol (5 mL) and stirred at ambient temperature. After 3.5 h, the solvent and excess methylamine were evaporated under reduced pressure and residue was partitioned between water (10 mL) and dichloromethane (10 mL). The organic layer was washed again with water (10 mL), dried (MgSO4), and concentrated to give the title amine (26) (120 mg, 76%) as a yellow oil:

Provenance & Evidence