3-(Trifluoromethyl)phenyl isocyanate → HCID 18613735, compound

HRID 1264914Notes

Reaction equation

HRID 1264914 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[CH:11][N:10]=[C:9]2[CH:15]([NH:17][CH3:18])[CH3:16])=[CH:4][CH:3]=1.[F:19][C:20]([F:31])([F:30])[C:21]1[CH:22]=[C:23]([N:27]=[C:28]=[O:29])[CH:24]=[CH:25][CH:26]=1>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[CH:11][N:10]=[C:9]2[CH:15]([N:17]([CH3:18])[C:28]([NH:27][C:23]2[CH:24]=[CH:25][CH:26]=[C:21]([C:20]([F:30])([F:31])[F:19])[CH:22]=2)=[O:29])[CH3:16])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 18613744HCID 18613744, compound

Product 1

HCID 18613735HCID 18613735, compoundYield 64.5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The amine (26) (12 mg, 0.05 mmol) and 3-trifluoromethylphenyl isocyanate (7.5 L, 0.05 mmol) were dissolved in chloroform (0.2 mL) and stirred at ambient temperature. After complete conversion of the starting material by TLC analysis, the solvent was removed and the resulting residue was subjected to silica-gel column chromatography [eluent: Dichloromethane] to give the title urea (27) (14 mg, quant.) as a solid:

Workup

  1. customAfter complete conversion of the starting material by TLC analysis, the solvent was removed

Sources & evidence

ORD record
ord-51578b57a4f44949a6bfae0324607b29
Source dataset
uspto-grants-2003_04
Patent number
US06545005B1

Reaction notes

Loading…