4-Chlorobenzoyl chloride → HCID 18613846, compound

HRID 1264916Notes

Reaction equation

HRID 1264916 reaction equation
Cl.[NH2:2][CH2:3][C:4]([C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=1)=[O:5].[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH:2][CH2:3][C:4]([C:6]2[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=2)=[O:5])=[O:23])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 18613865193813-77-3

Product 1

HCID 18613846HCID 18613846, compoundYield 54%

Procedure

In the same manner as in Reference Example 6, ethyl 4-(2-amino-1-oxoethyl)benzoate hydrochloride and 4-chlorobenzoyl chloride were condensed to obtain ethyl 4-[2-(4-chlorobenzoylamino)-1-oxoethyl]benzoate. Yield: 54%. NMR (CDCl3) δ 1.41 (3H, t, J=7 Hz), 4.43 (2H, q, J=7 Hz), 4.99 (2H, d, J=4 Hz), 7.23 (1H, brs), 7.46 (2H, d, J=8.5 Hz), 7.84 (2H, d, J=8.5 Hz), 8.09 (2H, d, J=8.5 Hz), 8.21 (2H, d, J=8.5 Hz).

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-dadd132d56bb4667a619eda50db24161
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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