HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Methyl 4-[4-(4-chlorophenyl)-2-oxazolyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | p-Chlorophenacyl bromide | HCID 68303 | — |
| Reactant | Methyl 4-carbamoylbenzoate | HCID 596094 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Methyl 4-[4-(4-chlorophenyl)-2-oxazolyl]benzoate | HCID 18613897 | 18% |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
A mixture of methyl 4-carbamoylbenzoate (4.67 g), 4-chlorophenacyl bromide (6.50 g) and N,N-dimethylformamide (5 ml) was stirred at 130° C. for 2 hours. Hot ethanol was added to the reaction mixture, which was filtered. The filtrate was cooled to obtain crystals of methyl 4-[4-(4-chlorophenyl)-2-oxazolyl]benzoate (1.45 g, Yield: 18%). The product was recrystallized from ethanol. Pale yellow prisms. Melting Point: 183 to 184° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06545009B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-9dd429ce3653460d904c96038eab3e6f |
| Source note | uspto-grants-2003_04 |