4-Chlorobenzamide → HCID 18613886, compound

HRID 1264922Notes

Reaction equation

HRID 1264922 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.Br[CH2:12][C:13]([C:15]1[CH:25]=[CH:24][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][CH:16]=1)=O>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[O:7][CH:12]=[C:13]([C:15]3[CH:25]=[CH:24][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][CH:16]=3)[N:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 120844-ChlorobenzamideHCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

Product 1

HCID 18613886HCID 18613886, compoundYield 49%

Procedure

In the same manner as in Example 1, 4-chlorobenzamide was reacted with ethyl 4-bromoacetylbenzoate to obtain ethyl 4-[2-(4-chlorophenyl)-4-oxazolyl)benzoate. The product was recrystallized from ethanol. Yield: 49%. Pale yellow prisms. Melting Point: 153 to 154° C.

Sources & evidence

ORD record
ord-3885fb3ab18040a1ad58a70271d119b0
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

Loading…