Hydrochloric Acid → 4-[4-(4-Chlorophenyl)-2-oxazolyl]benzoic acid

Participants

Reaction Steps

A mixture of methyl 4-[4-(4-chlorophenyl)-2-oxazolyl]benzoate (450 mg), a 1N aqueous solution of sodium hydroxide (2.5 ml), tetrahydrofuran (10 ml) and methanol (5 ml) was stirred at 60 to 70° C. for 20 minutes. The reaction mixture was poured into water. To the mixture was added 1N hydrochloric acid, and precipitated 4-[4-(4-chlorophenyl)-2-oxazolyl]benzoic acid (273 mg, Yield: 64%) was collected by filtration and then washed with water. The product was recrystallized from acetone-isopropyl ether to obtain pale yellow prisms. Melting Point: 283 to 284° C. (decomposition).

Provenance & Evidence