Methyl 4-carbamoylbenzoate → HCID 18613839, compound

HRID 1264925Notes

Reaction equation

HRID 1264925 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[O:3])[NH2:2].[F:14][C:15]([F:27])([F:26])[C:16]1[CH:17]=[C:18]([CH:23]=[CH:24][CH:25]=1)[C:19](=O)[CH2:20]Br>>[F:14][C:15]([F:26])([F:27])[C:16]1[CH:17]=[C:18]([C:19]2[N:2]=[C:1]([C:4]3[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=3)[O:3][CH:20]=2)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 596094Methyl 4-carbamoylbenzoateHCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

Product 1

HCID 18613839HCID 18613839, compoundYield 21%

Procedure

In the same manner as in Example 1, methyl 4-carbamoylbenzoate was reacted with 3-trifluoromethylphenacyl bromide to obtain methyl 4-[4-(3-trifluoromethylphenyl)-2-oxazolyl]benzoate. The product was recrystallized from ethanol. Yield: 21%. Pale yellow prisms. Melting Point: 134 to 135° C.

Sources & evidence

ORD record
ord-f09e2c04474d411687e21445d01c1757
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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