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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1264927Generated: October 25, 2026

Methyl 4-carbamoylbenzoate → Methyl 4-[4-(4-difluoromethoxylphenyl)-2-oxazolyl]benzoate

https://huagongshe.com/reaction/1264927

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-carbamoylbenzoateHCID 596094—
Reactant2-Bromo-1-(4-(difluoromethoxy)phenyl)ethan-1-oneHCID 703496—
ProductMethyl 4-[4-(4-difluoromethoxylphenyl)-2-oxazolyl]benzoateHCID 1861386021%

Reaction Steps

In the same manner as in Example 1, methyl 4-carbamoylbenzoate was reacted with 4-difluoromethoxylphenacyl bromide to obtain methyl 4-[4-(4-difluoromethoxylphenyl)-2-oxazolyl]benzoate. The product was recrystallized from ethanol. Yield: 21%. Pale yellow prisms. Melting Point: 160 to 161° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06545009B1
Source datasetuspto-grants-2003_04
ORD IDord-c88fa49dd84c4ec3b0764e11aff07171
Source noteuspto-grants-2003_04