4-(Trifluoromethyl)benzamide → HCID 18613858, compound

HRID 1264928Notes

Reaction equation

HRID 1264928 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][CH:4]=1.Br[CH2:15][C:16]([C:18]1[CH:28]=[CH:27][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:20][CH:19]=1)=O>>[F:1][C:2]([F:12])([F:13])[C:3]1[CH:11]=[CH:10][C:6]([C:7]2[O:8][CH:15]=[C:16]([C:18]3[CH:28]=[CH:27][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:20][CH:19]=3)[N:9]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 746844-(Trifluoromethyl)benzamideHCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

Product 1

HCID 18613858HCID 18613858, compoundYield 21%

Procedure

In the same manner as in Example 1, 4-trifluoromethylbenzamide was reacted with ethyl 4-bromoacetylbenzoate to obtain ethyl 4-[2-(4-trifluoromethylphenyl)-4-oxazolyl]benzoate. The product was recrystallized from ethanol. Yield: 21%. Pale yellow prisms. Melting Point: 168 to 170° C.

Sources & evidence

ORD record
ord-2d377b9d8ded4572860fd5f0246bfd97
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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