m-(Trifluoromethyl)benzamide → HCID 18613900, compound

HRID 1264929Notes

Reaction equation

HRID 1264929 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([NH2:8])=[O:7].Br[CH2:15][C:16]([C:18]1[CH:28]=[CH:27][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:20][CH:19]=1)=O>>[F:1][C:2]([F:12])([F:13])[C:3]1[CH:4]=[C:5]([C:6]2[O:7][CH:15]=[C:16]([C:18]3[CH:28]=[CH:27][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:20][CH:19]=3)[N:8]=2)[CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 74535m-(Trifluoromethyl)benzamideHCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

Product 1

HCID 18613900HCID 18613900, compoundYield 22%

Procedure

In the same manner as in Example 1, 3-trifluoromethylbenzamide was reacted with ethyl 4-bromoacetylbenzoate to obtain ethyl 4-[2-(3-trifluoromethylphenyl)-4-oxazolyl]benzoate. The product was recrystallized from ethanol. Yield: 22%. Pale yellow prisms. Melting Point: 132 to 133° C.

Sources & evidence

ORD record
ord-38ead041aeb84e9d84873d55db394dcd
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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