Benzoic acid, 3-(aminocarbonyl)-, methyl ester → HCID 15491314, compound

HRID 1264930Notes

Reaction equation

HRID 1264930 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[NH2:2].[F:14][C:15]([F:27])([F:26])[C:16]1[CH:25]=[CH:24][C:19]([C:20](=O)[CH2:21]Br)=[CH:18][CH:17]=1>>[F:14][C:15]([F:26])([F:27])[C:16]1[CH:17]=[CH:18][C:19]([C:20]2[N:2]=[C:1]([C:4]3[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=3)[C:7]([O:9][CH3:10])=[O:8])[O:3][CH:21]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 184711Benzoic acid, 3-(aminocarbonyl)-, methyl esterHCID 3219792-Bromo-4'-(trifluoromethyl)acetophenone

Product 1

HCID 15491314HCID 15491314, compoundYield 30%

Procedure

In the same manner as in Example 1, methyl 3-carbamoylbenzoate was reacted with 4-trifluoromethylphenacyl bromide to obtain methyl 3-[4-(4-trifluoromethylphenyl)-2-oxazolyl]benzoate. The product was recrystallized from ethanol. Yield: 30%. Pale yellow prisms. Melting Point: 151 to 152° C.

Sources & evidence

ORD record
ord-fc40aa92e2fb4f6ba523ef610b5d645f
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

Loading…