3-(2-Bromoacetyl)pyridine hydrobromide → HCID 18613847, compound

HRID 1264935Notes

Reaction equation

HRID 1264935 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].Br.[Br:15][CH2:16][C:17]([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)=O>>[BrH:15].[N:21]1[CH:22]=[CH:23][CH:24]=[C:19]([C:17]2[N:2]=[C:1]([C:4]3[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=3)[S:3][CH:16]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 27762343-(2-Bromoacetyl)pyridine hydrobromideHCID 11401319Methyl 4-carbamothioylbenzoate

Product 1

HCID 18613847HCID 18613847, compoundYield 80%

Procedure

In the same manner as in Example 28, methyl 4-thiocarbamoylbenzoate was reacted with 3-bromoacetylpyridine hydrobromide to obtain methyl 4-[4-(3-pyridyl)-2-thiazolyl]benzoate hydrobromide. The product was recrystallized from ethanol. Yield: 80%. Pale yellow prisms. Melting point: 241 to 242° C.

Sources & evidence

ORD record
ord-6a09a32327ec418c9990f6ad17a8b615
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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