4-(Bromoacetyl)pyridine hydrobromide → HCID 18613916, compound

HRID 1264936Notes

Reaction equation

HRID 1264936 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].Br.[Br:15][CH2:16][C:17]([C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)=O>>[BrH:15].[N:22]1[CH:23]=[CH:24][C:19]([C:17]2[N:2]=[C:1]([C:4]3[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=3)[S:3][CH:16]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 27762394-(Bromoacetyl)pyridine hydrobromideHCID 11401319Methyl 4-carbamothioylbenzoate

Product 1

HCID 18613916HCID 18613916, compoundYield 66%

Procedure

In the same manner as in Example 28, methyl 4-thiocarbamoylbenzoate was reacted with 4-bromoacetylpyridine hydrobromide to obtain methyl 4-[4-(4-pyridyl)-2-thiazolyl]benzoate hydrobromide. The product was recrystallized from ethanol. Yield: 66%. Pale yellow prisms. Melting point: 238 to 240° C.

Sources & evidence

ORD record
ord-4dff684f1ee14ef7a8b9670bc068643f
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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