2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one → HCID 18613820, compound

HRID 1264940Notes

Reaction equation

HRID 1264940 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].[F:14][C:15]([F:28])([F:27])[O:16][C:17]1[CH:26]=[CH:25][C:20]([C:21](=O)[CH2:22]Br)=[CH:19][CH:18]=1>>[F:14][C:15]([F:27])([F:28])[O:16][C:17]1[CH:18]=[CH:19][C:20]([C:21]2[N:2]=[C:1]([C:4]3[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=3)[S:3][CH:22]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 27786912-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-oneHCID 11401319Methyl 4-carbamothioylbenzoate

Product 1

HCID 18613820HCID 18613820, compoundYield 60%

Procedure

In the same manner as in Example 28, methyl 4-thiocarbamoylbenzoate was reacted with 4-trifluoromethoxyphenacyl bromide to obtain methyl 4-[4-(4-trifluoromethoxyphenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 60%. Pale yellow prisms. Melting point: 138 to 139° C.

Sources & evidence

ORD record
ord-004017f8f1bd4225bba2344d50eac424
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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