4-(Trifluoromethyl)thiobenzamide → HCID 18613862, compound

HRID 1264961Notes

Reaction equation

HRID 1264961 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[S:8])=[CH:5][CH:4]=1.Br[CH2:15][C:16]([C:18]1[CH:28]=[CH:27][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:20][CH:19]=1)=O>>[F:13][C:2]([F:1])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]2[S:8][CH:15]=[C:16]([C:18]3[CH:28]=[CH:27][C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:20][CH:19]=3)[N:9]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 27348234-(Trifluoromethyl)thiobenzamideHCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

Product 1

HCID 18613862HCID 18613862, compoundYield 56%

Procedure

In the same manner as in Example 74, 4-trifluoromethylthiobenzamide was reacted with ethyl 4-bromoacetylbenzoate to obtain ethyl 4-[2-(4-trifluoromethylphenyl)-4-thiazolyl)benzoate. The product was recrystallized from ethanol. Yield: 56%. Pale yellow prisms. Melting point: 163 to 164° C.

Sources & evidence

ORD record
ord-42b6b8f840564d668fdc0741253063b6
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

Loading…