Toluene → HCID 18613837, compound

Participants

Reaction Steps

A mixture of ethyl 4-[2-(4-chlorobenzoylamino)-1-oxoethyl]benzoate (1.04 g), phosphorus oxychloride (0.92 g) and toluene (10 ml) was refluxed under heating for 1 hour. The reaction mixture was poured into water, and precipitated crystals of ethyl 4-[2-(4-chlorophenyl)-5-oxazolyl]benzoate (560 mg, yield: 57%) were collected by filtration. The product was recrystallized from ethyl acetate-hexane to obtain pale yellow prisms. Melting point: 137to 138° C.

Provenance & Evidence