Lawesson's reagent → HCID 18613823, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 4-[2-(4-trifluoromethylbenzoylamino)-1-oxoethyl]benzoate (900 mg), Lawesson's reagent (960 mg) and xylene (5 ml) was stirred at 140 t 145° C. for 2 hours. The reaction mixture was cooled, and precipitated crystals of ethyl 4-[2-(4-trifluoromethylphenyl)-5-thiazolyl]benzoate (378 mg, yield: 43%) were collected by filtration. The product was recrystallized from xylene-isopropyl ether to obtain pale yellow prisms. Melting point: 174 to 176° C.

Provenance & Evidence