Lawesson's reagent → HCID 18613873, compound

HRID 1264967Notes

Reaction equation

HRID 1264967 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([CH2:8][NH:9][C:10]([C:12]2[CH:22]=[CH:21][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][CH:13]=2)=O)=O)=[CH:4][CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:34])=CC=1>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]2[S:34][C:10]([C:12]3[CH:22]=[CH:21][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][CH:13]=3)=[N:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 18613888HCID 18613888, compound

Product 1

HCID 18613873HCID 18613873, compoundYield 89%

Procedure

In the same manner as in Example 111, ethyl 4-[N-(4-chlorobenzoylmethyl)carbamoyl]benzoate was reacted with Lawesson's reagent to obtain ethyl 4-[5-(4-chlorophenyl)-2-thiazolyl]benzoate. The product was recrystallized from xylene-isopropyl ether. Yield: 89%. Pale yellow prisms. Melting point: 167 to 168° C.

Sources & evidence

ORD record
ord-0134d865d2864fd8bcc46435d6667aff
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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