Hydrochloric Acid → HCID 18613876, compound

Participants

Reaction Steps

A mixture of ethyl 4-[2-(4-trifluoromethylphenyl)-5-thiazolyl]benzoate (360 mg), a 1N aqueous solution of sodium hydroxide (3 ml), tetrahydrofuran (5 ml) and ethanol (5 ml) was stirred at 60 to 70° C. for 1 hour. The reaction mixture was poured into 1N hydrochloric acid, and precipitated 4-[2-(4-trifluoromethylphenyl)-5-thiazolyl]benzoic acid (150 mg, yield: 45%) was collected by filtration. The product was recrystallized from acetone-isopropyl ether to obtain pale yellow prisms. Melting point: 294 to 295° C.

Provenance & Evidence