(2S)-2β,5α-Dimethylpyrrolidine → HCID 131723846, compound

Participants

Role	Name	HCID	Charge
Reactant	(2S)-2β,5α-Dimethylpyrrolidine	HCID 5324511	—
Reactant	Ethyl (s)-3-[4-(3-methyl-2,7-naphthyridin-1-ylamino)phenyl]-2-[2-isopropoxy-3,4-dioxocyclobut-1-enylamino]propanoate	HCID 91509257	—
Product	HCID 131723846	HCID 131723846	—

Reaction Steps

Prepared in a similar manner to the compound of Example 33, from the compound of Example 30 and cis 2,5-dimethylpyrrolidine. δH (DMSO-d6), 9.75 (1H, s), 9.45 (1H, s), 8.56 (1H, d, J 5.6 Hz), 7.84 (2H, m), 7.65 (1H, d, J 9.1 Hz), 7.55 (1H, d, J 5.6 Hz), 7.23 (2H, d, J 8.5 Hz), 6.96 (1H, s), 5.13 (1H, m), 4.22-4.13 (4H, m), 3.22 (1H, dd, J 13.9, 4.6 Hz), 3.04 (1H, dd, J 13.8, 10.6 (Hz), 2.43 (3H, s), 2.12-2.05 (2H, m), 1.70-1.64 (2H, m), 1.24-1.15 (9H, m); m/z (ES+, 70V) 528 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06545013B2
Source dataset	uspto-grants-2003_04
ORD ID	ord-a29a8dfbab374f8a88bd6c1b9d56ae4b
Source note	uspto-grants-2003_04