HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 4-amino-3-iodobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 4-amino-3-iodobenzoate | HCID 459320 | 90.4% |
Reaction Steps
To a solution of ethyl 4-aminobenzoate (13.0 g) in DMF (33 mL) is added a solution of N-iodosuccinimide (18.6 g) in DMF (39 mL). The reaction is stirred at room temperature overnight. The mixture is poured into 800 mL water. The resulting solid is collected and dried to yield 20.7 g (90%) of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544990B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-ccd50fceb75c41f786232ebe20ae07e0 |
| Source note | uspto-grants-2003_04 |