HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Chloromethoxy)-2-methoxyethane → N-(4-chloro-5-methyl-3-isoxazolyl)-N-(methoxyethoxymethyl)thieno[2,3-b]pyridine-3-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Chloromethoxy)-2-methoxyethane | HCID 77590 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-(4-chloro-5-methyl-3-isoxazolyl)thieno[2,3-b]pyridine-3-sulfonamide | HCID 18614046 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(4-chloro-5-methyl-3-isoxazolyl)-N-(methoxyethoxymethyl)thieno[2,3-b]pyridine-3-sulfonamide | HCID 17894957 | 60.5% |
Reaction Steps
The title compound was prepared by the method of Example 4(A) using N-(4-chloro-5-methyl-3-isoxazolyl)thieno[2,3-b]pyridine-3-sulfonamide (0.30 g, 0.91 mmoles), EtOAc (30 ml), DIEA (0.24 ml, 1.4 mmoles) and MEM-Cl (0.11 ml, 1.0 mmoles). Flash chromatography (40% EtOAc/hexanes) provided 0.23 g (59%) of the title compound as a light yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06545014B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-9e331ad415db4ba5a28a3f3ebf14923b |
| Source note | uspto-grants-2003_04 |