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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265092Generated: October 25, 2026

trans-2-Phenylcyclopropyl isocyanate → N-{3-[4-amino-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl]propyl}-N'-[(1R*,2S)-2-phenylcyclopropyl]urea

https://huagongshe.com/reaction/1265092

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttrans-2-Phenylcyclopropyl isocyanateHCID 255285—
Reactant1-(3-aminopropyl)-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amineHCID 21973836—
ProductN-{3-[4-amino-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl]propyl}-N'-[(1R*,2S)-2-phenylcyclopropyl]ureaHCID 20575810—

Reaction Steps

Using the method of Examples 94-105, trans-2-phenylcyclopropyl isocyanate was reacted with 1-(3-aminopropyl)-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 437.2674.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06545017B1
Source datasetuspto-grants-2003_04
ORD IDord-508c74f6262b4ec1a4d53093c7338599
Source noteuspto-grants-2003_04