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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265097Generated: October 30, 2026

trans-2-Phenylcyclopropyl isocyanate → N-[2-(4-amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)ethyl]-N'-[(1R,2S)-2-phenylcyclopropyl]urea

https://huagongshe.com/reaction/1265097

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttrans-2-Phenylcyclopropyl isocyanateHCID 255285—
Reactant1-(2-aminoethyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amineHCID 21973820—
ProductN-[2-(4-amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)ethyl]-N'-[(1R,2S)-2-phenylcyclopropyl]ureaHCID 59049854—

Reaction Steps

Using the method of Examples 118-133, trans-2-phenylcyclopropyl isocyanate was reacted with 1-(2-aminoethyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 379.2235.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06545017B1
Source datasetuspto-grants-2003_04
ORD IDord-d26743aa569e4e269e5d8148c9847cc5
Source noteuspto-grants-2003_04