trans-2-Phenyl-1-cyclopropanecarbonyl chloride → 2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-{[(1R,2R)-2-phenylcyclopropyl]carbonyl}piperidin-4-yl)ethyl]-1H-imidazo[4,5-c]pyridin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	trans-2-Phenyl-1-cyclopropanecarbonyl chloride	HCID 13656	—
Reactant	2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine	HCID 12972962	—
Product	2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-{[(1R,2R)-2-phenylcyclopropyl]carbonyl}piperidin-4-yl)ethyl]-1H-imidazo[4,5-c]pyridin-4-amine	HCID 20575807	—

Reaction Steps

Using the method of Examples 61-75, trans-2-phenyl-1-cyclopropanecarbonyl chloride was reacted with 2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired product. The observed accurate mass was 476.3039.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06545016B1
Source dataset	uspto-grants-2003_04
ORD ID	ord-b203f51e56e545ab9bc1dc291d37cb7d
Source note	uspto-grants-2003_04