Hydrochloric Acid → HCID 9869528, compound

Participants

Reaction Steps

A solution of N-{3,5-dichloro-4-[4-hydroxy-3-(pyrrolidine-1-sulfonyl)-phenoxy]-phenyl}-oxamic acid ethyl ester (10 mg, 0.02 mmol) in a mixture of H2O (0.5 mL) and MeOH (0.5 mL) was added 2 drops of 3N KOH. The reaction mixture was stirred at RT for 2 h, acidified with 1N HCl and extracted with EtOAc (4×5 mL). The combined organic extracts were dried and concentrated to afford the title compound as an off-white solid. NMR (400 MHz, CD3OD) d 7.96 (s, 2H), 7.02-7.06 (m, 2H), 6.95-6.98 (d, 1H), 3.28-3.31 (m, 4H), 1.78-1.81 (m, 4H). MS Calc.: 474.3 Found: 473.1 (M−1).

Provenance & Evidence