Methanesulfonic Acid → HCID 18614155, compound

Participants

Reaction Steps

To a stirred solution of 2,2-dimethyl-7-hydroxy-4-methoxyindan-1-one (500 mg) and methanesulfonic acid (466 mg) in dichloromethane (12 mL) was added triethylsilane (564 mg). Every 0.5 h, over a 3 h period, additional portions of methanesulfonic acid and triethylsilane were added. The reaction was partitioned between water and dichloromethane, the organic layer dried over sodium sulfate, concentrated in vacuo and the resulting oil flash chromatographed (1:1, chloroform:hexanes) to afford 2,2-dimethyl-7-hydroxy-4-methoxyindane (230 mg) as a colorless waxy solid.

Provenance & Evidence