Dichloromethane → HCID 9928555, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound (3) (41 mg, 0.11 mmol) in CH2Cl2 (3 mL) m-CPBA (31.3 mg, 0.13 mmol) was added at −78° C. under N2. After 30 min. the reaction mixture was allowed to warm to −30° C. and stirred at −30° C. until the starting material disappeared completely. Aqueous Na2CO3 (10 mL) was then added and the organic phase was separated. The organic layer was washed with aq. Na2CO3 (10×4 mL), dried, concentrated to obtain a solid which was purified by flash chromatography on silica (20% EtOAc:hexane) to obtain the title compound (60%). 1H NMR (CDCl3) δ 7.78 (s, 2H), 7.45 (s, 1H), 7.53 (m, 2H), 4.01 (d, J=7.8 Hz, 1H), 3.88 (d, 7.8 Hz, 1H); MS (M+) 355.

Provenance & Evidence