Acetic Acid → HCID 18614742, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (86) (20.2 mg, 56.6 mmol) in 500 mL acetic acid was added chromium(VI) oxide (30 mg, 283 mmol). The mixture was stirred at 50° C. for 12 h. The solvent was removed under reduced pressure. The mixture was then chromatographed on a silica gel TLC plate using hexane/ethyl acetate (9:1) to give (87): Yield 76%): 1H NMR (400 MHz, CDCl3) δ 7.97 (s, 1H), 7.81 (s, 2H), 6.23 (dd, 1H, J=4.97, 55.81 Hz), 5.37 (ddd, 1H, J=4.97, 12.36, 47.15 Hz).

Provenance & Evidence