Sodium Bicarbonate → HCID 18614746, compound

Participants

Reaction Steps

To a solution of (91) (3.6 mg, 9.7 mmol) in 300 mL THF was added methyl magnesium bromide (50 mL, 3.0 M) at 0° C. The solution was then stirred at room temperature for 30 min. The mixture was poured into 5 mL of saturated NaHCO3 solution and extracted with dichlormethane (5 mL×3). The organic layers were combined, washed with brine, and dried with anhydrous sodium sulfate. The mixture was then chromatographed on a silica gel TLC plate using hexane/ethyl acetate (3:1) to give (93): yield 98%; 1H NMR (400 MHz, CDCl3) δ 7.73 (s, 2H), 7.47 (s, 1H), 3.65-3.31 (m, 2H), 2.46 (br s, 1H), 1.67 (s, 3H).

Provenance & Evidence