4-Bromobenzyl bromide → HCID 53889498, compound

Participants

Reaction Steps

The 4-[(3-hydroxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbonyl]benzoic acid methyl ester (from Example 7) was alkylated with 4-bromobenzylbromide as described for Example 60 to give 4-[(3-(4-bromobenzyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbonyl]benzoic acid methyl ester (60%): 1H NMR (400 MHz, CDCl3) δ 8.03 (1/2ABq, 2H, J=8.4 Hz, ArH), 7.80 (1/2ABq, 2H, J=8.4 Hz, ArH), 7.46 (s, 1H, ArH), 7.29 (1/2ABq, 2H, J=8.4 Hz, ArH), 6.87 (s, 1H, ArH), 6.81 (1/2ABq, 2H, J=8.4 Hz, ArH), 4.87 (s, 2H, OCH2), 3.97 (s, 3H, OCH3), 1.70 (m, 4H, 2CH2), 1.30 (s, 6H, 2CH3), 1.27 (s, 6H, 2CH3).

Provenance & Evidence