反应详情

1-(3-Hydroxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-naphthalen-2-yl)-ethanone (0.250 g, 1.01 mmol) was alkylated with isobutylbromide (0.195 g, 1.42 mmol, 0.154 mL) as described in Example 21. Aqueous workup gave 1-[3-isobutyloxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-naphthalen-2-yl]-ethanone 0.322 g (crude) as an orange oil: 1H-NMR (400 MHz, CDCl3) δ 7.74 (s, 1H, Ar—H), 6.81 (s, 1H, Ar—H), 4.13 (d, J=6.2 Hz, 2H, OCH2), 2.62 (s, 3H, CH3), 2.16 (m, 1H, CH), 1.68 (app br d, 4H, 2CH2), 1.30 (s, 6H, 2CH3), 1.28 (s, 6H, 2CH3), 1.08 (d, J=6.7 Hz, 6H, 2CH3).