Tetrahydrofuran → HCID 57052900, compound

Participants

Reaction Steps

A mixture of (1S,2R)-2-(3,5-difluorophenylcarbonyl)cyclohexanecarboxylic acid (1 g, 3.7 mmol), 10% Pd(OH)2 on carbon (1 g), tetrahydrofuran (10 mL) and acetic acid (0.5 mL) was shaken under hydrogen atmosphere at 50 psi for 96 h. The reaction mixture was filtered through Celite®, and filtrate and evaporated to give (1S,2R)-2-(3,5-difluorophenyl-methyl)cyclohexanecarboxylic acid, as a white solid (0.9 g, 95%).

Provenance & Evidence