反应详情

1-(4-Chloro-2-fluoro-5-hydroxyphenyl)-4-(3-fluoropropyl)-tetrazolinone (2.91 g) was gradually added into an ice-cooled nitric acid (20 ml) and stirred for 30 minutes. Crushed ice was added followed by extraction with ethyl acetate. The ethyl acetate extract was washed with water, dried over sodium sulfate, concentrated, and filtered through a silica gel SPE column (2 g) to give the title compound as a yellow solid (3.4 g).

1. additionCrushed ice was added
2. extractionfollowed by extraction with ethyl acetate
3. extractionThe ethyl acetate extract
4. washwas washed with water
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. filtrationfiltered through a silica gel SPE column (2 g)