Nitric Acid → HCID 57032799, compound

HRID 1265373Notes

Reaction equation

HRID 1265373 reaction equation
[Cl:1][C:2]1[C:7]([NH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][C:5]([N:14]2[C:19](=[O:20])[CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[NH:16][C:15]2=[O:25])=[C:4]([F:26])[CH:3]=1.S(=O)(=O)(O)O.[N+:32]([O-])([OH:34])=[O:33]>>[Cl:1][C:2]1[CH:3]=[C:4]([F:26])[C:5]([N:14]2[C:19](=[O:20])[CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[NH:16][C:15]2=[O:25])=[C:6]([N+:32]([O-:34])=[O:33])[C:7]=1[NH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric Acid2×HCID 57090489HCID 57090489, compound

Product 1

HCID 57032799HCID 57032799, compound

Procedure

3-(4-Chloro-5-ethoxycarbonylamino-2-fluorophenyl)-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione (XLVII) (1.0 g) was stirred with sulfuric acid (2 ml) at 0° C., then a mixture of nitric acid (1 ml) and sulfuric acid (1 ml) was dropwise added. After stirring at room temperature for 3 hr, it was poured into ice water (50 ml) and yellow crystals formed immediately which was filtered, washed with water and dried in fume hood overnight (0.5 g).

Workup

  1. additionwas dropwise added
  2. customformed immediately which
  3. filtrationwas filtered
  4. washwashed with water
  5. customdried in fume hood overnight (0.5 g)

Sources & evidence

ORD record
ord-154e86574a454a63beb41b86feebbca8
Source dataset
uspto-grants-2003_04
Patent number
US06545161B2

Reaction notes

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